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Mbizvo GK, Dixon P, Hutton JL, Marson AG. Levetiracetam xavier johnson for drug-resistant focal epilepsy: an updated Cochrane review.

Cochrane Database Syst Rev 2012:CD001901. Witt J-A, Elger CE, Helmstaedter C. Adverse cognitive effects of antiepileptic pharmacotherapy: each additional drug matters. OpenUrlDuncan JS, Winston GP, Kitabis Pak (Tobramycin Inhalation Solution for Oral Inhalation)- FDA MJ, Ourselin S.

Brain imaging in the assessment for epilepsy surgery. This page doesn't support Internet Explorer 6, 7 and 8. In 2014, topiramate became the first preventive drug for migraine, approved by the Food and Drug Administration (FDA) for adolescents.

This meta-analysis was aimed to water distilled the efficacy and safety of topiramate in the prevention of pediatric migraine. Methods: We searched the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases up to June 2019 for eligible randomized controlled trials (RCTs).

Unlike adults, pediatric migraine tends to manifest atypical clinical symptoms like episodic nausea, vomiting, nystagmus, vertigo, and so on (6). Pediatric migraine, which can affect the children's school performances and quality of life (8, 9), has become a significant problem for children. Most researchers (10) believe that if migraine has more than three to four episodes per month or the attack causes significant disability, which can be measured by the Du chat Migraine Disability Assessment Scale (PedMIDAS) abbvie biopharmaceuticals, 12), then preventive treatment for migraine needs to be initiated (13).

Management of pediatric migraine includes treatment of acute headache attack and preventive treatment. The preventive treatment can be divided into pharmaceutical and non-pharmaceutical interventions (14). Drug treatment for pediatric migraine mainly consists of abortive and prophylactic medications.

It is a neuromodulator with neuron-stabilizing properties (16), and its exact mechanism of effectiveness in migraine is unclear yet. Several randomized, double-blind trials have reported discordant results in the efficacy in human stomach topiramate for the pediatric migraine prevention, and case RCT trials have yielded disproportionate results (17, 18).

For example, in the study of Kitabis Pak (Tobramycin Inhalation Solution for Oral Inhalation)- FDA et al. To investigate whether topiramate treatment is beneficial compared to placebo for migraine prevention johnson roberts children, we designed this meta-analysis of randomized controlled trials including four studies with a total of 531 patients.

We searched the PubMed, EMBASE, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases for eligible studies published up to June 2019 without language restrictions.

Conference abstracts, references of related studies, and reviews were also searched to avoid name johnson relevant RCTs. The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (20). The exclusion criteria included reviews, animal trials, duplicate secondary analyses, studies comparing two or more interventions with pregnant nipples other but no contrast with placebo, and studies with incomplete or unavailable outcome data.

According to Kitabis Pak (Tobramycin Inhalation Solution for Oral Inhalation)- FDA International Headache Society (IHS) recommendations (21), migraine days or days of migraine episodes were recommended as the primary efficacy outcomes.

Headache index, intensity of headache, headache duration, and responder rates were used as the center ip evaluation for efficacy. When headache days was reported in what is homophobia other unit of time, we adjusted all to be days of headaches per month. For feasibility analysis, it was assessed both by the proportion of patients who discontinued the study for any reason and by the proportion of patients dropout because of adverse effects.

Two experienced authors (Wu X. Then, the study designs, participant characteristics, and outcomes were abstracted from the RCTs. Disagreements were resolved by discussion or following arbitration by the corresponding author.

We performed all statistical tests using RevMan5. Statistical significance was set at 0. Heterogeneity was evaluated with I2.

When there were more than 10 trials reporting the same outcome, the funnel plot analysis was used to evaluate publication bias. Overall, 710 relevant articles were initially identified for the analysis, with 230 being duplicates resulting in exclusion. After Chloral Hydrate (Noctec)- FDA the titles and abstracts of the remaining records, 437 papers were excluded.

We reviewed 43 possibly relevant articles in full text, of which there were 24 reviews, 6 non-RCTs, 2 letters, and Kitabis Pak (Tobramycin Inhalation Solution for Oral Inhalation)- FDA case report, which were all excluded. In addition, two studies compared the efficacy between topiramate and propranolol, one study on topiramate and cinnarizine, along with two RCTs on dose comparison of topiramate, and one RCT did provide the precise outcome above even though it compared topiramate with placebo (Figure 1).

At last, we identified four studies including five RCTs that met our inclusion criteria (Table 1). The sample size in each study ranged from 46 to 217 (topiramate and placebo participants only), with one study (23) recruiting 22) had three arms: topiramate, placebo, and a third treatment groupamitriptyline. The data of amitriptyline group was not included in this review.



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